Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance
نویسندگان
چکیده
منابع مشابه
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.
Errors are inherent in all biological systems. Errors in protein translation are particularly frequent giving rise to a collection of protein quasi-species, the diversity of which will vary according to the error rate. As mistranslation rates rise, these new proteins could produce new phenotypes, although none have been identified to date. Here, we find that mycobacteria substitute glutamate fo...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1317580111